Since about a year SQL 2008 R2 is a supported platform for System Center Configuration Manager. However, when you use the Reporting Services Server as apposed to the ConfigMgr Reporting you get an error every hour, stating your Reporting Services Point cannot be reached. When you connect to the point, it works without a problem though.
The exact message from the ConfigMgr console is:
SMS SRS web service is not running on SRS Reporting point server
The error has error message 7403.
Some time ago the SQL Server product team released a new Cumulative Update (CU) for SQL Server 2008 R2, which fixes the issue.
If you are encountering above mentioned issue, please download CU4 from http://support.microsoft.com/kb/2345451 and install it on the SQL server used for hosting the Site Database and Reporting Services.
Hope this helps.